The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease
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چکیده
منابع مشابه
The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease.
CONTEXT Somatic mutations in the ubiquitin-specific peptidase USP8 gene were recently detected in one- to two-third(s) of corticotroph adenomas of Cushing's disease (CD). These mutations may lead to the deubiquitination of EGFR, thereby increasing EGFR signaling, which has been implicated in ACTH hypersecretion. OBJECTIVE Our objective was to determine the impact of USP8 mutations on the clin...
متن کاملLack of Ubiquitin Specific Protease 8 (USP8) Mutations in Canine Corticotroph Pituitary Adenomas
PURPOSE Cushing's disease (CD), also known as pituitary-dependent hyperadrenocorticism, is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary tumours. Affected humans and dogs have similar clinical manifestations, however, the incidence of the canine disease is thousand-fold higher. This makes the dog an obvious model for studying the pathogenesis of pituitary-dependent hyperadren...
متن کاملSilent corticotroph adenomas.
Silent corticotroph pituitary adenomas (SCA) are defined as pituitary adenomas showing positive staining for adrenocorticotrophic hormone in immunohistochemical studies, but not associated with perioperative clinical or laboratory features of hypercortisolaemia. They account for 1.1-6% of surgically removed pituitary adenomas. Currently, two distinct pathologic subtypes of SCA are recognised. T...
متن کاملUSP8 mutation in Cushing's disease
Pituitary corticotroph adenomas, also referred to as Cushing’s disease (CD), secret large amounts of adrenocorticotropic hormone (ACTH), resulting in excess glucocorticoids and hypercortisolism [1]. The diagnosis of hypercortisolism is complicate and sometimes difficult because its clinical features overlap with other common diseases. Currently, 65-90% of patients achieve complete or partial re...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2016
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje-15-0689